Material Safety Data Sheet
Product No. 18420, 18421, 18422 Glutaraldehyde, 8%
Issue Date (06-15-06)
Review Date (04-06-07)
Section 1: Product and Company Identification
Product Name: Glutaraldehyde, 8%
Synonym: Glutaral, Glutaric Dialdehyde
Chemical Family: Aldehydes
Company Name
Ted Pella, Inc. and PELCO International, P.O. Box 492477, Redding,
CA96049-2477
Domestic Phone (800) 237-3526 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM
to 4:00PM PST)
International Phone (01) (530) 243-2200 (Mon-Thu. 6:00AM to 4:30PM PST; Fri 6:00AM to 4:00PM PST)
Chemtrec Emergency Number 1-800-424-9300 24 hrs a day.
Section 2: Composition / Information on Ingredients
|
Principle Hazardous Component(s)
|
% |
OSHA mg/m3 |
ACGIH |
OSHA mg/m3 |
ACGIH |
NTP |
IARC |
OSHA |
|
Glutaraldehyde (111-30-8) |
8 |
0.8 0.2ppm |
0.2* 0.05ppm* |
NE |
NE |
No |
No |
No |
|
Water (7732-18-5) |
<92.5 |
NE |
NE |
NE |
NE |
No |
No |
No |
|
Methanol (67-56-1) |
0.5 |
NE |
NE |
260 |
262 |
No |
No |
No |
*HI State: Activated and Inactivated.
Section 3: Hazard Identification
Emergency overview
Appearance: Transparent, colorless liquid.
Immediate effects: Danger! Corrosive. Causes irreversible eye damage. Cause skin burns. Maybe fatal if swallowed. Prolonged or frequently repeated skin contact may cause allergic reaction in some individuals. Plastic container, if present, may cause static ignition hazard. Aspiration may cause lung damage. Causes asthmatic signs and symptoms in hyper-reactive individuals.
Potential health effects
Primary Routes of entry: Inhalation, ingestion, and skin and eye contact.
Signs and Symptoms of Overexposure:
Eyes: Liquid will cause severe and persistent conjunctivitis, seen as excess redness
and marked swelling of the conjunctiva and profuse discharge. Severe corneal
injury may develop, which could permanently impair vision if prompt first-aid
and medical treatment not obtained. Vapor will cause stinging sensations in the
eye with excess tear production, blinking and possibly a slight excess of
redness of the conjunctiva.
Skin: Brief contact will cause itching with mild to moderate local redness and possibly swelling. Prolong contact may result in pain, severe redness and swelling with ulceration, tissue destruction and possibly bleeding into the inflamed area. Contact with solutions of Glutaraldehyde may cause harmless yellow or brownish coloration of skin. Skin Absorption: Prolonged or widespread contact may result in the absorption of potentially harmful amounts of material.
Ingestion: Moderately toxic. May cause moderate to marked irritation and possibly chemical burns of the mouth, throat, esophagus and stomach. There will be discomfort or pain in the chest and abdomen, nausea, vomiting, diarrhea, dizziness, faintness, drowsiness, thirst, weakness, circulator shock, collapse and coma. Aspiration into the lungs may occur during ingestion or vomiting, resulting in lung injury.
Inhalation: Vapor is irritating to the respiratory tract, causing stinging sensations in the nose and throat, discharge from nose, possibly bleeding from the nose, coughing, chest discomfort and tightness, difficulty with breathing and headache. Heating the solution may result in more sever irritant effects.
Chronic Exposure: Repeated skin contact may cause a cumulative dermatitis. May cause skin sensitization in a small portion of individuals and present as an allergic contact dermatitis. This usually results from contact with the liquid, but occasionally there may be a reaction to Glutaraldehyde vapor. Will cause signs and symptoms of an asthmatic attack in hyper-reactive individuals.
Chemical Listed As Carcinogen Or Potential Carcinogen:
See Toxicological Information (Section11)
Potential environmental effects
See Ecological Information (Section 12)
Section 4: First Aid Measures
If accidental overexposure is suspected
Eye(s) Contact: Immediately flush eyes with water and continue washing for at least 15 minutes. DO NOT remove contact lenses, if worn. Obtain medical attention without delay, preferably from an ophthalmologist.
Skin Contact: Immediately remove contaminated clothing and shoes. Wash skin
with soap and water. Obtain medical attention. Wash clothing before reuse.
Discard contaminated leather articles such as shoes and belt.
Inhalation: Remove to fresh air. Give artificial respiration if not breathing.
If breathing is difficult, oxygen may be given by qualified professional.
Obtain medical attention.
Ingestion: DO NOT INDUCE VOMITING. Do not give anything to drink. Obtain medical attention immediately.
Note to physician
Treatment: The hazards of this material are due mainly to its severely irritant properties on skin and mucosal surfaces. Moderately toxic by swallowing. Moderately toxic by absorption across the skin. Due to the severely irritating or corrosive nature of the material, swallowing may lead to ulceration and inflammation of the upper dimentary tract with hemorrhage and fluid loss. Also, perforation of the esophagus or stomach may occur, leading to mediastinitis or peritonitis and the resultant complications. Any material aspirated during vomiting may cause lung injury. Therefore, emesis should not be induced mechanically or pharmacologically. If it is considered necessary to evacuate the stomach contents, this should be done by means least likely to cause aspiration (e.g., gastric lavage after endotracheal intubation).
Medical Conditions generally Aggravated by Exposure: Skin contact may aggravate an existing dermatitis. Inhalation of material may aggravate asthma and inflammatory of fibrotic pulmonary disease.
Section 5: Fire Fighting Measures
Flash Point: ND
Flammable Limits: ND
Auto-ignition point: ND
Fire Extinguishing Media: Non-flammable (aqueous solution). After water evaporates,
remaining material will burn. Use alcohol-type or dl-purpose-type foam, applied
by manufacturer’s recommended techniques for large fires. Use carbon dioxide in
sufficient concentrations can act as an asphyxiant.
Special Fire Fighting Procedures: Use self-contained breathing apparatus and
protective clothing.
Unusual Fire and Explosion Hazards: None known.
Hazardous combustion products: Carbon monoxide, carbon dioxide.
DOT Class: None
Section 6: Accidental Release Measures
Steps to be Taken in Case Material is Released or Spilled: Very low
concentrations (5 ppm or less of Glutaraldehyde) can be degraded in a
biological waste water treatment system. Small spills can be flushed with large
amounts of water. Large Spills: Material should be collected for disposal. It
may also be possible to decontaminate spilled material by careful application
of sodium hydroxide, ammonium or sodium bisulfate. Depending on conditions,
considerable heat and fumes can be liberated by decontamination of reaction.
Toxic to fish; avoid discharge to natural waters.
Waste Disposal Methods: Dispose of waste according to Federal, State and Local
Regulations.
Section 7: Handling and Storage
Precautions to be Taken in Handling and Storage: Must not be used in the form
of a spray or aerosol. Do not get in eyes, on skin or clothing. Avoid breathing
vapors. Do not swallow. Do not handle or empty in presence of flammable vapor.
Wear goggles, protective clothing and gloves. Wash thoroughly with soap and
water after handling. Remove contaminated clothing and wash before reuse. Keep
container closed and use adequate ventilation.
Storage temperature: ND
Storage Pressure: ND
Section 8: Exposure Controls / Personal Protection
Engineering Controls
Ventilation required: General mechanical room ventilation is expected to be satisfactory if this material is kept in covered equipment or if the solution is highly diluted. However, if vapors are strong enough to be irritating to the nose or eyes, the TLV is probably being exceeded and special ventilation is required.
Personal Protection Equipment
Respiratory protection: Use self-contained breathing apparatus in high vapor concentrations. If apparatus is not available, a MSHA/NIOSH approved air purifying respirator equipped with an organic vapor cartridge should be used.
Protective gloves: Polyethylene, Nitrile (NBR) or Butyl gloves must be worn.
Skin protection: Wear protective chemical apron and rubber boots.
Eye protection: Splash proof mono-goggles or safety glasses with side shields
in conjunction with face shield.
Additional clothing and/or equipment: Eye bath and safety shower.
Exposure Guidelines
See Composition/Information on Ingredients (Section2)
Section 9 Physical and Chemical Properties
Appearance and Physical State: Transparent, colorless liquid.
Odor (threshold): Sharp, fruity, medicinal.
Specific Gravity (H2O=1): 1.129 @ 20 °C
Vapor Pressure (mm Hg): 0.03 kPa active ingredient (0.20 mmHg active ingredient)
Vapor Density (air=1): 1.1
Percent Volatile by volume: ND
Evaporation Rate (butyl acetate=1): 1
Boiling Point: 100.5 °C (213 °F) as product.
Freezing point / melting point: -21 °C (-6 °F)
pH: ND
Solubility in Water: 100% @ 20 °C
Molecular Weight: 100.11 g/mol
Chemical Formula: OHCC3H6CHO
Section 10: Stability and Reactivity
Stability: Stable
Conditions to Avoid: High temperatures above 100 °C and evaporation of water.
Materials to Avoid (Incompatibility): Strong alkalies and acids catalyze on aldol-type condensation exothermic, but not expected to be violent).
Hazardous Decomposition Products: ND
Hazardous Polymerization: Will not occur under 100 °C. However, if it does
occur, it is not hazardous.
Section 11: Toxicological Information
Results of component toxicity test performed: Acute Toxicity: Peroral, Rat (female), LD50: 154 (116-206) mg/kg. Major signs: sluggishness, lacrimation, diarrhea, piloerection, perinasal encrustation. Grass pathology: lungs, stomach, intestines discolored. Peroral, Rat (Male) LD50: 246 (179-339) mg/kg. Major signs: sluggishness, lacrimation, diarrhea, piloerection, perinasal encrustation. Grass pathology: lungs, stomach, intestines discolored. Percutaneous, Rabbit (24hrs occluded) LD50: 2.54 (1.46-4.41) ml/kg. Major signs: necrosis at application site. Grass pathology: lungs, livers, spleen and kidneys discolored.
Inhalation, Rat(Female): Dynamic generation of vapor.
Exposure Time: 4 hrs 163 ppm
Kill Rate: 0/5
Major Signs: Blepharospasm, periocular wetness, audible respiration.
Grass Pathology: None.
Inhalation, Rat(Female): Static generation of substantially saturated vapor.
Exposure Time: 4hrs @ 20 °C
Kill Rate: 0/5
Major Signs: Blepharospasm
Grass Pathology: None.
Inhalation, Rat(Male): Dynamic generation of vapor
Exposure Time: 4h 16.3 ppm @ room temperature
Kill Rate: 0/5
Major Signs: blepharospasm, periocular wetness, audible respiration
Gross Pathology: None.
Inhalation, Rat(Male): Static generation of substantially saturated vapor
Exposure Time: 4h @ 20 °C
Kill Rate: 0/5
Major Signs: blepharospasm
Gross Pathology: None
(Inhalation): Aerosol
Exposure Time: 4h
LC50: 0.48 (0.41-0.59) ml/l
Major Signs: heavy or irregular breathing, nasal discharge, gasping, nasal encrustation
Gross Pathology: lungs discolored.
IRRITATION:
(Skin: Rabbit): 4 hr covered 2/6 with necrosis
(Skin, Rabbit): 1 hr occluded minor to severe erythema and edema with necrosis, scabbing, desquamation, and alopecia
(Skin, Rabbit): 3 min occluded minor erythema
(Eye, Rabbit): 0.005 ml severe corneal injury, iritis, swelling and necrosis of eyelid
(Eye, Rabbit): 0.5ml 5% solution in water severe corneal injury, iritis, swelling and necrosis of eyelid.
(Eye, Rabbit): 0.5ml 1% solution in water traces corneal injury
SENSITIZATION:
Guinea Pig Maximization Test: intradermal injection of a 0.1% glutaraldehyde solution and topical administration of a 5% solution. Evidence of delayed contact hypersensitivity in 68% of test animals upon challenge.
CHRONIC TOXICITY AND CARCINOGENICITY:
Subchronic drinking water studies in rats, mice and dogs using Glutaraldehyde concentrations up to 1000 ppm showed no evidence for any target organ toxicity. In vitro studies for genotoxicity using a variety of assays have given results varying from no activity, through equivocal, to weakly positive; however, in all vivo studies for genotoxicity have been uniformly negative. Several developmental toxicity studies have demonstrated that a maternally nontoxic doses, glutaraldehyde does not produce fetotoxic, embryotoxic or teratogenic effects. In chronic (2-year) continuous drinking water combined chronic toxicity-oncogenicity study using Fischer 344 rats, there was no evidence for non-oncogenic target organ toxicity. T he only possible oncogenicity-related finding was an increase in the incidence of large granular cell lymphocytic leukemia in female, but not male, rats. The pattern of the response suggests that it does not represent direct chemical carcinogenic activity but, rather, a modifying influence on the expression of this spontaneous and commonly occurring neoplasm in the Fischer 344 rat.
Human experience: Studies in humans have shown that glutaraldehyde is neither phototoxic nor a photosensitizer. Subchronic drinking water studies in rats, mice and dogs using concentrations up to 1000 ppm showed no evidence for any target organ toxicity. In vitro studies for genotoxicity using a variety of assays have given results varying from no activity through equivocal, to weakly positive; however, all in vivo studies for genotoxicity have been uniformly negative. Several developmental toxicity studies have demonstrated that at maternally nontoxic doses, glutaraldehyde does not produce fetotoxic, embryotoxic or teratogenic effects. In a two-generation reproduction study involving continuous exposure of CD rats to glutaraldehyde up to 1000 ppm, in drinking water there were effects on parental body weight and food consumption at 1000 ppm (due to an aversion to the taste), but no adverse effects on reproductive performance. In a chronic 2-year) continuous drinking water combined chronic toxicity-oncogenicity study using Fischer 344 rats; there was no evidence for nononcogenic target organ toxicity. The only possible oncogenicity-related finding was an increase in the incidence of large granular cell lymphocytic leukemia in female, but not male, rats. The pattern of the response suggests that it does not represent direct chemical carcinogenic activity but, rather, a modifying influence on the expression of this spontaneous and commonly occurring neoplasm in the Fischer 344 rat. Repeated applications of aqueous solutions of glutaraldehyde to the rat skin for 20 doses over a 28-day period at 50,100, or 150 mg/kg/day produced mild local inflammatory effects, but no evidence for target organ or tissue systemic toxicity. An extensive clinical survey has been conducted on nursing staff in 59 endoscopy units (340 currently employed workers and 18 former employees); investigational procedures included detailed questionnaire, sensitization to common allergens, and blood for IgE measurements, lung function tests, peak flow diaries, and measurement of workplace glutaraldehyde vapor concentrations. About two-thirds of current employees had ocular, nasal, or lower respiratory tract symptoms, but these were more prevalent for non-work conditions. The only effect correlated with glutaraldehyde exposure was nasal irritation. There was a slight, but no statistically or biologically significant, decrease in FEVI for those with lower respiratory tract symptoms. There were no indications of asthma and no objective evidence for respiratory sensitization.
This product does not contain any compounds listed by NTP or IARC or regulated by OSHA as a carcinogen.
Section 12: Ecological Information
Ecological Information:
BOD (% Oxygen Consumption)
--------------------------
Day 5 Day 10 Day 15 Day 20 Day 30
32% 68% 86%
Ecotoxicity to Micro Organisms: Bacterial/NA LC50 16 h 50 mg/l
Ecotoxicity to Aquatic Invertebrates: Daphnia LC50 48 h 11.5 mg/l
Confidence Limits: 9.4 - 14.2 mg/l
Ecotoxicity to Fish: Blue gill LC50 96 h 22 mg/l
Further Information: ThOD (measured) 1.00
Chemical Fate Information: ND
Section 13 Disposal Considerations
RCRA 40 CFR 261 Classification: Not listed. Atomize into a very hot incinerator fire or mix with a suitable flammable solvent, and incinerate where permitted under appropriate Federal, State and local regulations. High water content may dampen flame. Empty containers should be recycled or disposed of through an approved waste management facility.
Federal, State and local laws governing disposal of materials can differ. Ensure proper disposal compliance with proper authorities before disposal.
Section 14: Transportation Information
US DOT Information: Proper shipping name: Non-hazardous from stand point of shipping.
IATA: Proper shipping name: Non-hazardous from stand point of shipping.
IMO: Proper shipping name: ND
Marine Pollutant: No
Canadian TDG: Non-hazardous from stand point of shipping.
Section 15: Regulatory Information
United States Federal Regulations
MSDS complies with OSHA’s Hazard Communication Rule 29, CFR 1910.1200.
The following components of this product are listed as extremely hazardous substances in 40 CFR Part 355 and are present at levels which could require reporting and emergency planning: None
Section 313: The following components of this product are listed as
toxic chemicals in 40 CFR 372.65 and are present at levels which could require
reporting and customer notification under Section 1 313 and 40 CFR Part 372.
This product does not contain toxic chemicals at levels which could require
reporting under this statute.
RCRA: Not listed
TSCA: All components of this product are on the TSCA inventory or are exempt from TSCA inventory requirements.
CERCLA: None
State Regulations
California Proposition 65: This product contains no listed substances known to the State of California to cause cancer, birth defects or other reproductive harm, at levels which would require a warning under the statute.
Pennsylvania (Worker and Community Right-to-Know Act): This product is subject to the Worker and Community Right-to-Know Act. The following components of this product are at levels which could require identification in the MSDS: Glutaraldehyde (111-30-8) ≤8.0000%
Massachusetts (Hazard Substances Disclosure by Employers): The following components of this product appear on the Massachusetts Substance List and are present at levels which could require identification in the MSDS: Glutaraldehyde (111-30-8) ≤8.0000%
California SCAQMD Rule 443.1, VOC: Not applicable.
International Regulations
Canada WHMIS: This product contains material listed on the CPR Inventory list.
Europe EINECS Numbers: Glutaraldehyde (111-30-8): EINECS#: 203-856-5. Water (7732-18-5): EINECS#: 231-791-2. Methanol (67-56-1): EINECS#: 200-659-6.
Section 16: Other Information
Label Information: ND
European Risk and Safety Phrases: ND
European symbols needed: ND
Canadian WHMIS Symbols: ND
HMIS® Rating: Health: 3; Fire: 0; Reactivity: 1
NFPA Rating: Health: 2; Fire: 0; Reactivity:
1
(0=least, 1=Slight, 2=Moderate, 3=High, 4=Extreme)
Abbreviations used in this document
NE= Not established
NA= Not applicable
NIF= No Information Found
ND= No Data
Disclaimer
Ted Pella, Inc. makes no warranty of any kind regarding the information furnished
herein. Users should independently determine the suitability and completeness
of information from all sources. While this data is presented in good faith and
believed to be accurate, it should be considered only as a supplement to other
information gathered by the user. It is the User's responsibility to assure the
proper use and disposal of these materials as well as the safety and health of
all personnel who may work with or otherwise come in contact with these
materials.
MSDS Form 0013F1 V2